2. Signaling Pathways
  3. GPCR/G Protein
  4. LPL Receptor

LPL Receptor

Lysophospholipid Receptor

LPL Receptor

Related Products

PDF 1.08 MB

LPL Receptor (Lysophospholipid Receptor) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling. In humans, there are eight LPL receptors, each encoded by a separate gene. These LPL receptor genes are also sometimes referred to as "Edg". LPL receptor ligands bind to and activate their cognate receptors located in the cell membrane. Depending on which ligand, receptor, and cell type is involved, the activated receptor can have a range of effects on the cell. These include primary effects of inhibition of adenylyl cyclase and release of calcium from the endoplasmic reticulum, as well as secondary effects of preventingapoptosis and increasing cell proliferation. Type: LPAR1, LPAR2, LPAR3, LPAR4, LPAR5, LPAR6, S1PR1, S1PR2, S1PR3, S1PR4, S1PR5.

LPL Receptor Isoform Specific Products:

LPL Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-119221A
    AUY 954 hydrochloride
    		Agonist
    AUY 954 hydrochloride is a potent and selective sphingosine-1-phosphate (S1P(1)) receptor agonist, exhibiting significant immunomodulatory activity. AUY 954 hydrochloride induces a profound and reversible reduction of circulating lymphocytes upon oral administration. AUY 954 hydrochloride has demonstrated efficacy in prolonging cardiac allograft survival when used in combination with RAD001 in a stringent transplantation model. AUY 954 hydrochloride effectively prevents experimental autoimmune neuritis in rats, showcasing its therapeutic potential in autoimmune conditions.
    AUY 954 hydrochloride
  • HY-120611
    BMS-960 free base
    		Agonist
    BMS-960 free base is a potent and selective S1P1 receptor agonist containing isoxazole, which can be used in the research of immune diseases and vascular diseases.
    BMS-960 free base
  • HY-156565
    S1P1 agonist 6
    		Agonist
    S1P1 agonist 6 (Compound I) is a S1P1 agonist that reduces autoimmune ability by blocking the transportation of lymphocytes. S1P1 agonist 6 can be used as an immunosuppressive agent in the study of various autoimmune diseases research.
    S1P1 agonist 6
  • HY-129808
    VPC12249
    		Antagonist
    VPC12249 is a competitive dual LPA1/LPA3 antagonist with Ki values of 137nM and 428 nM, respectively. VPC12249 inhibits calcium mobilization in HEK293T cells with a Ki value of ~130 nM. VPC12249 is promising for research of ovarian cancer and hypertensive diseases.
    VPC12249
  • HY-15381R
    Fingolimod phosphate (Standard)
    		Agonist
    Fingolimod phosphate (Standard) is the analytical standard of Fingolimod phosphate. This product is intended for research and analytical applications. Fingolimod phosphate (FTY720 phosphate) is an orally active sphingosine 1-phosphate (S1P) receptor agonist. Fingolimod phosphate can promote the neuroprotective effects of microglia. Fingolimod phosphate can be used for the research of multiple sclerosis and neurologic diseases.
    Fingolimod phosphate (Standard)
  • HY-175984
    S1P1 agonist 7
    		Agonist
    S1P1 agonist 7 is a potent, orally active, and β-arrestin-biased S1P1 agonist (EC50(G‑protein) = 12.7 nM and EC50(β‑arrestin) = 3.23 nM). S1P1 agonist 7 demonstrates potent immunomodulatory activity and a favorable safety profile. S1P1 agonist 7 exhibits excellent metabolic stability, minimal to moderate CYP inhibition, and S1P3-sparing selectivity. S1P1 agonist 7 shows pharmacokinetics, effectively reduces circulating lymphocytes, and significantly alleviates disease severity in experimental autoimmune encephalomyelitis (EAE) mouse models under both prophylactic and therapeutic regimens. S1P1 agonist 7 can be used for multiple sclerosis (MS) research.
    S1P1 agonist 7
  • HY-118539
    NSC12404
    		Agonist
    NSC12404 is a weak and specific LPA2 receptor agonist.
    NSC12404
  • HY-162655A
    SLF80821178 hydrochloride
    		Inhibitor
    SLF80821178 hydrochloride is an orally active inhibitor for sphingosine-1-phosphate transporter (Spns2), that inhibits the sphingosine-1-phosphate (S1P) release in HeLa with an IC50 of 51 nM. SLF80821178 hydrochloride reduces the circulating lymphocyte without affecting plasma S1P levels in mice.
    SLF80821178 hydrochloride
  • HY-116088
    W123
    		Antagonist
    W123, a FTY720 analog, is a competitive sphingosine 1-phosphate type 1 (S1P1) receptor antagonist. W123 is measured by GTPγS activation, MAPK recruitment, cell migration, and ligand-induced receptor internalization.
    W123
  • HY-149004B
    SLF1081851 hydrochloride
    SLF1081851 (hydrochloride) is a Spns2 inhibitor, inhibits S1P release (IC50=1.93 μM). SLF1081851 (hydrochloride) plays a key role in the development and immune system.
    SLF1081851 hydrochloride
  • HY-173509
    ATX inhibitor 27
    		Inhibitor
    ATX inhibitor 27 (Compound 31) is an ATX inhibitor. The IC50 values of ATX inhibitor 27 against human autotaxin (hATX) and lysophosphatidylcholine (LPC) are 13 nM and 23 nM, respectively. ATX inhibitor 27 reduces LPA levels in vivo by inhibiting ATX enzyme. ATX inhibitor 27 can be used in the study of ATX-LPA-related diseases such as inflammation, neurodegenerative diseases and cancer.
    ATX inhibitor 27
  • HY-163128
    SPL-IN-1
    		Inhibitor
    SPL-IN-1 (compound C17) is a dual species sphingosine-1-phosphate lyase inhibitor.
    SPL-IN-1
  • HY-175084
    1-Hexadecyl lysophosphatidic acid sodium
    		Activator
    1-Hexadecyl lysophosphatidic acid (1-Hexadecyl LPA) sodium, an ether analog of lysophosphatidic acid (LPA), is a LPA receptor activator.
    1-Hexadecyl lysophosphatidic acid sodium
  • HY-120633
    BMS-986104
    		Modulator
    BMS-986104 is a potent and selective S1P1 receptor modulator. BMS-986104 is effective in a mouse EAE model, which is comparable to FTY720. Mechanistically, BMS-986104 exhibites excellent remyelinating effects on lysophosphatidylcholine (LPC)-induced demyelination in a three-dimensional brain cell culture assay.
    BMS-986104
  • HY-108492
    TC-SP 14
    		Agonist
    TC-SP 14 (compound 14) is an orally active and potent S1P1 agonist (EC50 = 0.042 μM) with minimal activity at S1P3 (EC50 = 3.47 μM). TC-SP 14 significantly reduces blood lymphocyte counts and attenuates a delayed type hypersensitivity (DTH) response to antigen challenge.
    TC-SP 14
  • HY-RS12398
    S1pr3 Mouse Pre-designed siRNA Set A
    		Inhibitor

    S1pr3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for S1pr3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    S1pr3 Mouse Pre-designed siRNA Set A
  • HY-RS12397
    S1PR3 Human Pre-designed siRNA Set A
    		Inhibitor

    S1PR3 Human Pre-designed siRNA Set A contains three designed siRNAs for S1PR3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    S1PR3 Human Pre-designed siRNA Set A
  • HY-RS12393
    S1pr1 Rat Pre-designed siRNA Set A
    		Inhibitor

    S1pr1 Rat Pre-designed siRNA Set A contains three designed siRNAs for S1pr1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    S1pr1 Rat Pre-designed siRNA Set A
  • HY-115566
    S1PL-IN-1
    		Inhibitor
    S1PL-IN-31 (compound ) is an oral active sphingosine-1-phosphate (S1P) lyase inhibitor with the IC50 of 210 nM. S1PL-IN-31 is Smoothened receptor antagonist with the IC50 of 440 nM. S1PL-IN-31 can be used for study of experimental autoimmune encephalomyelitis.
    S1PL-IN-1
  • HY-139555
    Zectivimod
    		Agonist 99.35%
    Zectivimod is a sphingosine-1-phosphate receptor agonist. Zectivimod can be used for the research of autoimmune diseases，chronic inflammatory diseases and immunoregulation disorders.
    Zectivimod
Cat. No. Product Name / Synonyms Application Reactivity
LPL Receptor Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.