2. Signaling Pathways
  3. GPCR/G Protein
  4. LPL Receptor

LPL Receptor

Lysophospholipid Receptor

LPL Receptor

Related Products

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LPL Receptor (Lysophospholipid Receptor) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling. In humans, there are eight LPL receptors, each encoded by a separate gene. These LPL receptor genes are also sometimes referred to as "Edg". LPL receptor ligands bind to and activate their cognate receptors located in the cell membrane. Depending on which ligand, receptor, and cell type is involved, the activated receptor can have a range of effects on the cell. These include primary effects of inhibition of adenylyl cyclase and release of calcium from the endoplasmic reticulum, as well as secondary effects of preventingapoptosis and increasing cell proliferation. Type: LPAR1, LPAR2, LPAR3, LPAR4, LPAR5, LPAR6, S1PR1, S1PR2, S1PR3, S1PR4, S1PR5.

LPL Receptor Isoform Specific Products:

LPL Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-149004B
    SLF1081851 hydrochloride
    SLF1081851 (hydrochloride) is a Spns2 inhibitor, inhibits S1P release (IC50=1.93 μM). SLF1081851 (hydrochloride) plays a key role in the development and immune system.
    SLF1081851 hydrochloride
  • HY-173509
    ATX inhibitor 27
    		Inhibitor
    ATX inhibitor 27 (Compound 31) is an ATX inhibitor. The IC50 values of ATX inhibitor 27 against human autotaxin (hATX) and lysophosphatidylcholine (LPC) are 13 nM and 23 nM, respectively. ATX inhibitor 27 reduces LPA levels in vivo by inhibiting ATX enzyme. ATX inhibitor 27 can be used in the study of ATX-LPA-related diseases such as inflammation, neurodegenerative diseases and cancer.
    ATX inhibitor 27
  • HY-163128
    SPL-IN-1
    		Inhibitor
    SPL-IN-1 (compound C17) is a dual species sphingosine-1-phosphate lyase inhibitor.
    SPL-IN-1
  • HY-120633
    BMS-986104
    		Modulator
    BMS-986104 is a potent and selective S1P1 receptor modulator. BMS-986104 is effective in a mouse EAE model, which is comparable to FTY720. Mechanistically, BMS-986104 exhibites excellent remyelinating effects on lysophosphatidylcholine (LPC)-induced demyelination in a three-dimensional brain cell culture assay.
    BMS-986104
  • HY-108492
    TC-SP 14
    		Agonist
    TC-SP 14 (compound 14) is an orally active and potent S1P1 agonist (EC50 = 0.042 μM) with minimal activity at S1P3 (EC50 = 3.47 μM). TC-SP 14 significantly reduces blood lymphocyte counts and attenuates a delayed type hypersensitivity (DTH) response to antigen challenge.
    TC-SP 14
  • HY-RS12398
    S1pr3 Mouse Pre-designed siRNA Set A
    		Inhibitor

    S1pr3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for S1pr3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    S1pr3 Mouse Pre-designed siRNA Set A
    S1pr3 Mouse Pre-designed siRNA Set A
  • HY-RS12397
    S1PR3 Human Pre-designed siRNA Set A
    		Inhibitor

    S1PR3 Human Pre-designed siRNA Set A contains three designed siRNAs for S1PR3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    S1PR3 Human Pre-designed siRNA Set A
    S1PR3 Human Pre-designed siRNA Set A
  • HY-RS12393
    S1pr1 Rat Pre-designed siRNA Set A
    		Inhibitor

    S1pr1 Rat Pre-designed siRNA Set A contains three designed siRNAs for S1pr1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    S1pr1 Rat Pre-designed siRNA Set A
    S1pr1 Rat Pre-designed siRNA Set A
  • HY-115566
    S1PL-IN-1
    		Inhibitor
    S1PL-IN-31 (compound ) is an oral active sphingosine-1-phosphate (S1P) lyase inhibitor with the IC50 of 210 nM. S1PL-IN-31 is Smoothened receptor antagonist with the IC50 of 440 nM. S1PL-IN-31 can be used for study of experimental autoimmune encephalomyelitis.
    S1PL-IN-1
  • HY-139555
    Zectivimod
    		Agonist 99.35%
    Zectivimod is a sphingosine-1-phosphate receptor agonist. Zectivimod can be used for the research of autoimmune diseases，chronic inflammatory diseases and immunoregulation disorders.
    Zectivimod
  • HY-156565A
    S1P1 agonist 6 hemicalcium
    		Agonist
    S1P1 agonist 6 hemicalcium (Compound I) is a S1P1 agonist that reduces autoimmune ability by blocking the transportation of lymphocytes. S1P1 agonist 6 hemicalcium can be used as an immunosuppressive agent in the study of various autoimmune diseases research.
    S1P1 agonist 6 hemicalcium
  • HY-P0103
    Myristoyl pentapeptide-17
    Myristoyl pentapeptide-17 can stimulate eyelash growth by stimulating keratin production. Myristoyl pentapeptide-17 promotes the delivery of key ingredients in the serum, such as the growth factors and lysophosphatidic acid.
    Myristoyl pentapeptide-17
  • HY-139061
    Palmitoyl 3-carbacyclic phosphatidic acid
    Palmitoyl 3-carbacyclic phosphatidic acid (HY-139061) is a palmitoylated Carba-like cyclophosphatidic acid and an analog of lysophosphatidic acid (LPA). Palmitoyl 3-carbacyclic phosphatidic acid has different functions from LPA and can inhibit the activation of RhoA and inhibit the migration of melanoma cells. Palmitoyl 3-carbacyclic phosphatidic acid effectively inhibited experimental lung metastasis and reduced the number of tumor nodules in a B16-F0 xenograft mouse model.
    Palmitoyl 3-carbacyclic phosphatidic acid
  • HY-120611A
    BMS-960
    		Agonist
    BMS-960 is a potent and selective S1P1 receptor agonist containing isoxazole, which can be used in the research of immune diseases and vascular diseases.
    BMS-960
  • HY-RS12392
    S1pr1 Mouse Pre-designed siRNA Set A
    		Inhibitor

    S1pr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for S1pr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    S1pr1 Mouse Pre-designed siRNA Set A
    S1pr1 Mouse Pre-designed siRNA Set A
  • HY-110314
    CYM50358 hydrochloride
    		Antagonist
    CYM50358 hydrochloride (compound 4v) is a potent, selective sphingosine-1-phosphate 4 (S1P4) receptor antagonist. CYM50358 hydrochloride can be used in the study of influenza infection.
    CYM50358 hydrochloride
  • HY-P0103A
    Myristoyl pentapeptide-17 acetate
    Myristoyl pentapeptide-17 acetate can stimulate eyelash growth by stimulating keratin production. Myristoyl pentapeptide-17 acetate promotes the delivery of key ingredients in the serum, such as the growth factors and lysophosphatidic acid.
    Myristoyl pentapeptide-17 acetate
  • HY-162996
    Spns2-IN-2
    		Inhibitor
    Spns2-IN-2 (compund 3a) is a SPNS2 inhibitor.
    Spns2-IN-2
  • HY-143864
    S1PR1 agonist 1
    		Agonist
    S1PR1 agonist 1 is a potent agonist of S1PR1. Sphingosine-1-phosphate (S1P) is a cell membrane-derived lysophospholipid signalling molecule that exerts its physiological functions mainly by stimulating some members of the G protein-coupled receptor family. S1PR1 agonist 1 has the potential for the research of autoimmune diseases (extracted from patent WO2021175223A1, compound 22).
    S1PR1 agonist 1
  • HY-136577
    RP101442
    		Agonist
    RP101442, an active metabolite of Ozanimod, is a selective, potent S1PR1 (sphingosine-1-phosphate receptor 1) agonist, with EC50s of 2.6 nM and 171 nM for S1PR1 and S1PR5, respectively.
    RP101442
Cat. No. Product Name / Synonyms Application Reactivity
LPL Receptor Isoform Comparison

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